cell

Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation.

Authors:

Garcia-Herrera A; Song JY; Chuang SS; Villamor N; Colomo L; Pittaluga S; Alvaro T; Rozman M; de Anda Gonzalez J; Arrunategui AM; Fernandez E; Gonzalvo E; Estrach T; Colomer D; Raffeld M; Gaulard P; Campo E; Jaffe ES; Martinez A

Author Address:

Department of Pathology, Hospital Clinic, IDIBAPS, Barcelona, Spain.

Source:

The American Journal Of Surgical Pathology [Am J Surg Pathol] 2011 Aug; Vol. 35 (8), pp. 1214-25.

Publication Type:

Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

Language:

English

Journal Information:

Country of Publication: United States NLM ID: 7707904 Publication Model: Print Cited Medium: Internet ISSN: 1532-0979 (Electronic) Linking ISSN: 01475185 NLM ISO Abbreviation: Am. J. Surg. Pathol. Subsets: MEDLINE

MeSH Terms:

Lymphoma, T-Cell/*immunology Lymphoma, T-Cell, Cutaneous/*immunology Receptors, Antigen, T-Cell, gamma-delta/*analysis Skin Neoplasms/*immunology T-Lymphocytes, Cytotoxic/*immunology Adolescent ; Adult ; Aged ; Female ; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor ; Genes, T-Cell Receptor gamma ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization ; Lymphoma, T-Cell/genetics ; Lymphoma, T-Cell/pathology ; Lymphoma, T-Cell, Cutaneous/genetics ; Lymphoma, T-Cell, Cutaneous/pathology ; Male ; Middle Aged ; Paraffin Embedding ; Polymerase Chain Reaction ; Receptors, Antigen, T-Cell, alpha-beta/analysis ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; T-Lymphocytes, Cytotoxic/pathology ; Young Adult

Abstract:

γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)β expression has been used to infer a γδ origin when other methods are not available. We studied 35 T-cell tumors suspected to be γδ TCL using monoclonal antibodies reactive with TCR δ or γ in paraffin sections. We were able to confirm γδ chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 γδ TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy-associated T-cell lymphoma, type II. The other γδ TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCRβ expression does not always predict γδ-T-cell derivation, as TCR silent cases may be found. The recognition of γδ TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.

Contributed Indexing:

Indexing Agency: NLM Local ID #: NIHMS298476 [Available on 08/01/12].

Substance Nomenclature:

0 (Receptors, Antigen, T-Cell, alpha-beta) 0 (Receptors, Antigen, T-Cell, gamma-delta)

Entry Dates:

Date Created: 20110714 Date Completed: 20110913

Update Code:

20110913

PubMed Central ID:

PMC3136885 [Available on 08/01/12]

PMID:

21753698

Database:

MEDLINE with Full Text